Shudo E, Yang J, Yoshimura A, Iwasa Y.
Robustness of the signal transduction system of the mammalian JAK/STAT pathway and dimerization steps.
J Theor Biol. 2006 Dec 15; [Epub ahead of print]

Yajima T, Yasukawa H, Jeon ES, Xiong D, Dorner A, Iwatate M, Nara M, Zhou H, Summers-Torres D, Hoshijima M, Chien KR, Yoshimura A, Knowlton KU.
Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling.
Circulation. 2006 Nov 28;114(22):2364-73.

Lu Y, Fukuyama S, Yoshida R, Kobayashi T, Saeki K, Shiraishi H, Yoshimura A, Takaesu G.
Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic.
J Biol Chem. 2006 Dec 1;281(48):36683-90.

Yoshimura T, Takeda A, Hamano S, Miyazaki Y, Kinjyo I, Ishibashi T, Yoshimura A, Yoshida H.
Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.
J Immunol. 2006 Oct 15;177(8):5377-85.

Shiraishi H, Okamoto H, Yoshimura A, Yoshida H.
ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.
J Cell Sci. 2006 Oct 1;119(Pt 19):3958-66.

Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, Villarino AV, Huang Q, Yoshimura A, Sehy D, Saris CJ, O'Shea JJ, Hennighausen L, Ernst M, Hunter CA.
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.
Nat Immunol. 2006 Sep;7(9):937-45. Epub 2006 Aug 13.

Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS.
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.
Cell Metab. 2006 Aug;4(2):123-32.

Takaki H, Minoda Y, Koga K, Takaesu G, Yoshimura A, Kobayashi T.
TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.
Genes Cells. 2006 Aug;11(8):871-82.

Ogata H, Kobayashi T, Chinen T, Takaki H, Sanada T, Minoda Y, Koga K, Takaesu G, Maehara Y, Iida M, Yoshimura A.
Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.
Gastroenterology. 2006 Jul;131(1):179-93.

Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H.
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.
Nat Med. 2006 Jul;12(7):829-34

Yoshimura A.
Signal transduction of inflammatory cytokines and tumor development.
Cancer Sci. 2006 Jun;97(6):439-47. Review.

Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A.
IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice.
J Exp Med. 2006 Jun 12;203(6):1391-7.

Yamagishi S, Nakamura K, Matsui T, Inagaki Y, Takenaka K, Jinnouchi Y, Yoshida Y, Matsuura T, Narama I, Motomiya Y, Takeuchi M, Inoue H, Yoshimura A, Bucala R, Imaizumi T
Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression.
J Biol Chem. 2006 Jul 21;281(29):20213-20.

Chen Z, Laurence A, Kanno Y, Pacher-Zavisin M, Zhu BM, Tato C, Yoshimura A, Hennighausen L, O'Shea JJ.
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.
Proc Natl Acad Sci U S A. 2006 May 23;103(21):8137-42.

Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A.
A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.
Biochem Biophys Res Commun. 2006 Jun 9;344(3):1023-30. Epub 2006 Apr 19. Erratum in: Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121.

Dai X, Sayama K, Yamasaki K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yahata Y, Yang L, Yoshimura A, Hashimoto K.
SOCS1-negative feedback of STAT1 activation is a key pathway in the dsRNA-induced innate immune response of human keratinocytes.
J Invest Dermatol. 2006 Jul;126(7):1574-81.

Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A.
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1.
J Exp Med. 2006 Apr 17;203(4):1021-31.

Chinen T, Kobayashi T, Ogata H, Takaesu G, Takaki H, Hashimoto M, Yagita H, Nawata H, Yoshimura A.
Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved.
Gastroenterology. 2006 Feb;130(2):373-88.

Moriyama M, Matsukawa A, Kudoh S, Takahashi T, Sato T, Kano T, Yoshimura A, Kojima M.
The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock.
Biochem Biophys Res Commun. 2006 Mar 24;341(4):1149-54.

Kobayashi T, Takaesu G, Yoshimura A.
Mal-function of TLRs by SOCS.
Nat Immunol. 2006 Feb;7(2):123-4.

Yamada S, Tsukada J, Yoshimura A, Kubo M.
Computer simulation of the role of SOCS family protein in helper T cell differentiation.
Int Immunol. 2006 Feb;18(2):335-45.

Shouda T, Hiraoka K, Komiya S, Hamada T, Zenmyo M, Iwasaki H, Isayama T, Fukushima N, Nagata K, Yoshimura A.
Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant soft tissue tumor cells.
Cancer Lett. 2006 Jan 18;231(2):176-84.

Moriyama M, Fukuyama S, Inoue H, Matsumoto T, Sato T, Tanaka K, Kinjyo I, Kano T, Yoshimura A, Kojima M.
The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia.
Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L971-7.

Sekine Y, Yumioka T, Yamamoto T, Muromoto R, Imoto S, Sugiyma K, Oritani K, Shimoda K, Minoguchi M, Akira S, Yoshimura A, Matsuda T.
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.
J Immunol. 2006 Jan 1;176(1):380-9.

Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I.
Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system.
J Biol Chem. 2006 Feb 17;281(7):4495-506.

Qasimi P, Ming-Lum A, Ghanipour A, Ong CJ, Cox ME, Ihle J, Cacalano N, Yoshimura A, Mui AL.
Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumor necrosis factor alpha and nitric oxide production by macrophages.
J Biol Chem. 2006 Mar 10;281(10):6316-24.