(2004) -20
Kawaguchi T, Yoshida T, Harada M, Hisamoto T, Nagao Y, Ide T, Taniguchi E, Kumemura H, Hanada S, Maeyama M, Baba S, Koga H, Kumashiro R, Ueno T, Ogata H, Yoshimura A, Sata M.  Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3. Am J Pathol. 165:1499-1508, 2004

Yamagishi S, Abe R, Inagaki Y, Nakamura K, Sugawara H, Inokuma D, Nakamura H, Shimizu T, Takeuchi M, Yoshimura A, Bucala R, Shimizu H, Imaizumi T Minodronate, a newly developed nitrogen-containing bisphosphonate, suppresses melanoma growth and improves survival in nude mice by blocking vascular endothelial growth factor signaling.  Am J Pathol.;165:1865-18674, 2004.

Yamagishi S, Inagaki Y, Nakamura K, Abe R, Shimizu T, Yoshimura A, Imaizumi T.    Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation. J Mol Cell Cardiol. 2004 Aug;37(2):497-506.

Kuriyama M, Taniguchi T, Shirai Y, Sasaki A, Yoshimura A, Saito N.  Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Biochem Biophys Res Commun. 325:843-851, 2004.

Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A.    Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.  J Biol Chem. 279:52543-52551, 2004.

Inagaki-Ohara K, Chinen T, Matsuzaki G, Sasaki A, Sakamoto Y, Hiromatsu K, Nakamura-Uchiyama F, Nawa Y, Yoshimura A.  Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. J Immunol. 173:1390-1398, 2004.

Miyoshi K, Wakioka T, Nishinakamura H, Kamio M, Yang L, Inoue M, Hasegawa M, Yonemitsu Y, Komiya S, Yoshimura A.    The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization. Oncogene. 23: 5567-5576, 2004.

Kazemi S, Papadopoulou S, Li S, Su Q, Wang S, Yoshimura A, Matlashewski G, Dever TE, Koromilas AE.    Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. Mol Cell Biol. 24:3415-34129, 2004.

.Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, and Yoshimura A SOCS3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity Nature Mediciene 10: 739-743, 2004

Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, Sata M, Nagai, H and Yoshimura A  SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis  J Exp Med. 199: 1701-1707, 2004

Murakoshi H, Iino R, Kobayashi T, Fujiwara T, Ohshima C, Yoshimura A, Kusumi A.Single-molecule imaging analysis of Ras activation in living cells. Proc Natl Acad Sci U S A. 101; 7317-7322, 2004

Yamada S, Taketomi T, Yoshimura A.    Model analysis of difference between EGF pathway and FGF pathway. Biochem Biophys Res Commun. 314:1113-1120, 2004.

Nobuhisa I, Kato R, Inoue H, Takizawa M, Okita K, Yoshimura A, Taga T.  Spred-2 Suppresses Aorta-Gonad-Mesonephros Hematopoiesis by Inhibiting MAP Kinase Activation.  J Exp Med. 199:737-742, 2004.

Kamio M, Yoshida T, Ogata H, Douchi T, Nagata Y, Inoue M, Hasegawa M, Yonemitsu Y, Yoshimura A. SOCS1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein. Oncogene 17,3108-3116, 2004

Qu L, Huang S, Baltzis D, Rivas-Estilla AM, Pluquet O, Hatzoglou M, Koumenis C, Taya Y, Yoshimura A, Koromilas AE.Å@ Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3{beta}  Genes Dev. 18:261-277, 2004.

Gatto L, Berlato C, Poli V, Tininini S, Kinjyo I, Yoshimura A, Cassatella MA, Bazzoni F. Analysis of suppressor of cytokine signaling (SOCS)-3 promoter responses to interferon. J Biol Chem. 279:13746-13754, 2004

Joo A, Aburatani H, Morii E, Iba H, Yoshimura A. STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression.  Oncogene., 23: 726-734, 2004.

Kimura A, Kinjyo I, Matsumura Y, Mori H, Mashima R, Harada M, Chien KR, Yasukawa H, Yoshimura A.  SOCS3 is a physiological negative regulator for granulopoiesis and G-CSF receptor signaling. J Biol Chem.  297; 6905-6910, 2004

Fischer P, Lehmann U, Sobota RM, Schmitz J, Niemand C, Linnemann S, Haan S, Behrmann I, Yoshimura A, Johnston JA, Muller-Newen G, Heinrich PC, Schaper F. The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitisation of interleukin-6 signalling.
Biochem J.  378: 449-460, 2004

Yamanaka A, Hamano S, Miyazaki Y, Ishii K, Takeda A, Mak TW, Himeno K, Yoshimura A, Yoshida H.    Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis. J Immunol. 2004;172: 3590-3596.