(2003) -25
Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity.Å@Nat Immunol. 2003, 4: 1169-1176.

Yoshimura A, Mori H, Ohishi M, Aki D, Hanada T.  Negative regulation of cytokine signaling influences inflammation. Curr Opin Immunol. 2003, 15: 704-708.

Inagaki-Ohara K, Hanada T, Yoshimura A.  Negative regulation of cytokine signaling and inflammatory diseases.  Curr Opin Pharmacol. 2003, 3;  435-442.

Hamano S, Himeno K, Miyazaki Y, Ishii K, Yamanaka A, Takeda A, Zhang M, Hisaeda H, Mak TW, Yoshimura A, Yoshida H. WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity. 2003, 19: 657-667.

Hanada T, Yoshida H, Kato S, Tanaka K, Masutani K, Tsukada J, Nomura Y, Mimata H, Kubo M, Yoshimura A.    Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Immunity. 2003; 19: 437-450.

Seki Y, Inoue H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, Cacalano N, O'Garra A, Oshida T, Saito H, Johnston JA, Yoshimura A, Kubo M.: SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses Nature Medicine 2003, 9, 1047-1054

Yamamoto T, Yumioka T, Sekine Y, Sato N, Minoguchi M, Yoshimura A, Matsuda T. Regulation of Fc varepsilon RI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells. Biochem Biophys Res Commun. 2003 ;306:767-773.

Yasukawa H, Ohishi M,  Mori H,  Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien KR, and Yoshimura A; IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages Nature Immunol. 2003; 4, 551-556

Saeki K,  Miura Y,  Aki D, Kurosaki T,  and  Yoshimura  A; The B cell-specific major raft protein, Raftlin is necessary for the integrity of lipid raft and BCR signal transduction. EMBO J   2003, 22:3015-3026

Hanada T, Kinjyo I, Inagaki-Ohara K, Yoshimura A. Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases. Rev Physiol Biochem Pharmacol  2003; 149: 72-86

Sasaki,A, Taketomi T, Kato R, Saeki K, Nonami A,  Sasaki M, Kuriyama M,Saito N,Shibuya M, Yoshimura A. Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1 Nature Cell Biol. 2003, 5:427-432.

Shibata R, Kai H, Seki Y, Kato S, Wada Y, Hanakawa Y, Hashimoto K, Yoshimura A, Imaizumi T. Inhibition of STAT3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells. Human Gene Therapy  2003, 14: 601-610.

Nagata T, Kai H, Shibata R, Koga M, Yoshimura A, Imaizumi T. Oncostatin M, an IL-6 family cytokine, upregulates matrix metalloproteinase-9 through the MEK-ERK pathway in cultured smooth miscle cells. Arteriosclerosis, Thrombosis, Vascular Biology  2003, 23: 588-593.

Minoguchi S, Minoguchi M, Yoshimura A. Differential control of the NIMA-related kinases, Nek6 and Nek7, by serum stimulation. Biochem Biophys Res Commun. 2003;301: 899-906.

Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU.  The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury.  J Clin Invest. 2003, 111: 469-478.

Matsumoto A, Seki YI, Watanabe R, Hayashi K, Johnston JA, Harada Y, Abe R, Yoshimura A, Kubo M. A Role of Suppressor of Cytokine Signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated Interleukin 2 Production. J Exp Med. 2003, 197: 425-436.

Du L, Frick GP, Tai LR, Yoshimura A, Goodman HM. Interaction of the growth hormone receptor with cytokine-induced SRC homology domain 2 protein in rat adipocytes. Endocrinology  2003, 144: 868-876.
 
Endo T, Sasaki A, Minoguchi M, Joo A, and Yoshimura A. CIS1 interacts with the Y532 of the Prolactin Receptor and Suppresses Prolactin-Dependent STAT5 Activation 2003. J. BioChem 133, 109-113

Minoguchi M, Minoguchi S, Aki D, Joo A, Yamamoto T, Yumioka T, Matsuda T, Yoshimura A. STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.  J Biol Chem. 2003 278: 11182-11189

Sasaki A, Inagaki-Ohara K, Yoshida T, Yamanaka A, Sasaki M, Yasukawa H, Koromilas AE,Yoshimura A. The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. J Biol Chem.Å@2003 278:2432-2436

Wollberg P, Lennartsson J, Gottfridsson E, Yoshimura A, Ronnstrand L. The adapter protein APS associates to the multifunctional docking sites Tyr568 and Tyr936 in c-Kit: possible role in v-Kit transformation. Biochem J.  2003 , 370 1033-1038

Yamada S, Shiono S, Joo A, Yoshimura A.     Control mechanism of JAK/STAT signal transduction pathway. FEBS Lett. 2003 ;534:190-196.

Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I,Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F. SHP2 and SOCS3 contribute to Y759-dependent attenuation of IL-6-signaling through gp130. J Biol Chem. 2003  278: 661-671

Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A
Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Biochem Biophys Res Commun. 2003;302:767-772.

Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A.    Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Cell Cycle. 2003;2(4):281-282.