(2000)  -8
Sakamoto H, Kitamura T and Yoshimura A; Mitogen-Activated Protein Kinase Plays an Essential Role in the Erythropoietin-Dependent Proliferation of CTLL-2 Cells. J Biol Chem 275 : 35857-35862, 2000.

Iwamoto T, Senga T, Naito Y, Matsuda S, Miyake Y, Yoshimura A and Hamaguchi M;    The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activation. Oncogene 19 : 4795-801, 2000.

Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I and Yoshimura A; CIS3/SOCS3 suppresses erythropoietin signaling by binding the EPO receptor and JAK2. J Biol Chem 275 : 29338-29347, 2000.

Seki Y, Kai H, Shibata R, Nagata T, Yasukawa H, Yoshimura A and Imaizumi T; Role of the JAK/STAT Pathway in Rat Carotid Artery Remodeling After Vascular Injury. Circ Res  87 : 12-18, 2000.

Supino-Rosin L, Yoshimura A, Yarden Y, Elazar Z and Neumann D; Intracellular Retention and Degradation of the Epidermal Growth Factor Receptor - Two Distinct Processes Mediated by Benzoquinone Ansamycins. J Biol Chem 275 : 21850-21855, 2000.

Yasukawa H, Sasaki A and Yoshimura A; Negative Regulation of Cytokine Signaling Pathways. Annu Rev Immunol 18 : 143-164, 2000.

Matsuda T, Yamamoto T, Kishi H, Yoshimura A and Muraguchi A; SOCS-1 can suppress CD3zeta- and Syk-mediated NF-AT activation in a non-lymphoid cell line. FEBS Lett 472 : 235-240. 2000.

Ward AC, Touw I and Yoshimura A; The jak-stat pathway in normal and perturbed hematopoiesis. Blood 95 : 19-29, 2000.

(<1999)
Marine J-C, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A and Ihle JN; SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis. Cell 98 : 617-627, 1999.

Marine J-C, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A and Ihle JN; SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality. Cell 98 : 609-616, 1999.

Yokouchi M, Kondo T, Houghton A, Bartkiewicz M, Horne WC, Zhang H, Yoshimura A and Baron R; Ligand-induced Ubiquitination of the EGF Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7. J Biol Chem 274 : 31707-31712, 1999.

Supino-Rosin L, Yoshimura A, Altaratz H and Neumann D; A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation. Eur J Biochem 263 : 410-419, 1999.

Aman MJ, Migone TS, Sasaki A, Ascherman DP, Zhu Mh, Soldaini E, Imada K, Miyajima A, Yoshimura A and Leonard WJ; CIS Associates with the Interleukin-2 Receptor beta Chain and Inhibits IL-2-Dependent Signaling. J Biol Chem 274 : 30266-30272, 1999.

Cassatella MA, Gasperini S, Bovolenta C, Calzetti F, Vollebregt M, Scapini P, Marchi M, Suzuki R, Suzuki A and Yoshimura A; Interleukin-10 (IL-10) Selectively Enhances CIS3/SOCS3 mRNA Expression in Human Neutrophils: Evidence for an IL-10-Induced Pathway That Is Independent of STAT Protein Activation. Blood 94 : 2880-2889, 1999.

Cohney SJ, Sanden D, Cacalano NA, Yoshimura A, Mui A, Migone TS and Johnston JA; SOCS-3 Is Tyrosine Phosphorylated in Response to Interleukin-2 and Suppresses STAT5 Phosphorylation and Lymphocyte Proliferation. Mol Cell Biol 19 : 4980-4988, 1999.

Matsumoto A, Seki Y, Kubo M, Ohtsuka S, Suzuki A, Hayashi I, Tsuji K, Nakahata T, Okabe M, Yamada S and Yoshimura A; Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice. Mol Cell Biol 19 : 6396-6407, 1999.

Chida D, Miura O, Yoshimura A and Miyajima A; Role of Cytokine Signaling Molecules in Erythroid Differentiation of Mouse Fetal Liver Hematopoietic Cells: Functional Analysis of Signaling Molecules by Retrovirus-Mediated Expression. Blood 93 : 1567-1578, 1999.

Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka A, Imaizumi T, Matsuda T, Ihle JN and Yoshimura A; The JAK-Binding Protein JAB Inhibits Janus Tyrosine Kinase Activity Through Binding in the Activation Loop. EMBO J 18 : 1309-1320, 1999.

Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S and Yoshimura A; APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl, and inhibits PDGF-induced mitogenesis. Oncogene 18 : 759-768, 1999.

Okajima Y, Matsumura I, Nishiura T, Hashimoto K, Yoshida H, Ishikawa J, Wakao H, Yoshimura A, Kanakura Y, Tomiyama Y and Matsuzawa Y; Insulin-like growth factor-I augments erythropoietin-induced proliferation through the enhanced tyrosine phosphorylation of STAT5. J Biol Chem 273 : 22877-22883, 1998.

Verdier F, Chretien S, Muller O, Varlet P, Yoshimura A, Gisselbrecht S, Lacombe C and Mayeux P; Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation. J Biol Chem 273 : 28185-28190, 1998.

Chida D, Wakao H, Yoshimura A and Miyajima A; Transcriptional regulation of the b-casein gene by cytokines: cross-talk between STAT5 and other signaling molecules. Mol Endocrinol 12 : 1792-1806, 1998.

Sakamoto H, Yasukawa H, Masuhara M, Tanimura S, Sasaki A, Yuge K, Ohtsubo M, Ohtsuka S, FujitaT, Ohta T, Furukawa Y, Iwase S, Yamada H and Yoshimura A; A Janus kinase inhibitor, JAB, is an interferon-g inducible gene and confers resistance to interferons. Blood 92 : 1668-1676, 1998.

Suzuki R, Sakamoto H, Yasukawa H, Masuhara M, Wakioka T, Sasaki A, Yuge K, Yokouchi M, Komiya S, Inoue A and Yoshimura A; CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells. Oncogene 17 : 2271-2278, 1998.

Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanekura Y, Komiya S and Yoshimura A; A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387 : 921-924, 1997.

Matsumoto A, Masuhara M, Mitsui K, Yokouchi M, Ohtsubo M, Misawa H, Miyajima A and Yoshimura A; CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89 : 3148-3154, 1997.

Iwatsuki K, Endo T, Misawa H, Yokouchi M, Matsumoto A, Ohtsubo M, Mori JK and Yoshimura A; STAT5 Activation Correlates with Erythropoietin Receptor-Mediated Erythroid Differentiation of an Erythroleukemia Cell Line. J Biol Chem 272 : 8149-8153, 1997.

Yokouchi, M., Suzuki, R., Masuhara, M., Komiya, S., Inoue, A., and Yoshimura, A. Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.
Oncogene   15, 7-15, 1997

Yoshimura, A, Ichihara, M., Kinjyo, I., Moriyama, M., Copeland, N.G., Gilbert, D.J., Jenkins, N.A.,      Hara, T., Miyajima, A.  :Mouse oncostatin M: an immediate early response gene induced by multiple cytokines through the JAK/STAT5 pathway.  EMBO J. 15, 1055-1063, 1996 
 
Yoshimura, A. , Ohkubo, T., Kiguchi, T., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Hara, T., and Miyajima, A. :  A novel cytokine-inducible gene  CIS encodes an SH2-contanining protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14, 2816-2826, 1995

Hara, T., Bacon,K.B., Cho, L.C., Yoshimura, A., Morikawa, Y., Copeland, N.G.,  Miyajima A., et al.:  Molecular cloning and functional characterization of a novel member of the C-C chemokine family.   J. Immunol.  155,  5352-5358, 1995
 
Yoshimura, A :  Second subunit of EPO receptor? Nature 372, 137-138, 1994

Ohashi, H., Maruyama, K., Liu, Y. and  Yoshimura, A.:  Ligand-induced  activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases.   Proc. Natl. Acad. Sci. USA.   91, 158-162, 1994

Maruyama, K., Miyata, K., and  Yoshimura, A. : Proliferation and erythroid differentiation  through the cytoplasmic domain of the erythropoietin receptor.
 J. Biol. Chem.  269, 5976-5980, 1994

Youssoufian, H., Logmore, G., Newmann, D., Yoshimura, A., Lodish, H. F.:  Structure,   function, and activation of the erythropoietin receptor.  Blood 81, 2223-2236, 1993

Yoshimura, A. and Lodish, H. F.:  In vitro phosphorylation of the erythropoietin
  receptor and an associated protein,  pp130.  Mol. Cell. Biol.  12,  706-715, 1992

Watowich, S. S., Yoshimura, A., Longmore, G., Hilton, D. J., Yoshimura, Y.,  and
Lodish, H. F.: Homodimerization and constitutive activation of the erythropoietin receptor.     Proc. Natl. Acad. Sci. USA. 89, 2140-2144, 1992

Yoshimura, A., Zimmers, T., Neumann, D., Longmore, G., Yoshimura, Y.,and  Lodish,  H. F.: Mutations in theTtp-Ser-X-Trp-Ser motif  of the erythropoietin receptor abolish  processing, ligand binding, and activation of the receptor.
J. Biol. Chem.  267, 11619-11625, 1992

Yoshimura, A., Longmore, G. and Lodish, H. F.:  Point mutation in the exoplasmic  domain of the erythropoietin receptor resulting in hormone-independent  activation and  tumorigenecity.  Nature 348, 647-649, 1990

Yoshimura, A., D'Andrea, A. D. and Lodish, H. F.:  Friend spleen focus forming virus  glycoprotein gp55 interacts with  erythropoietin receptor in the endoplasmic reticulum  and affects receptor metabolism.  Proc. Natl. Acad. Sci. USA. 87, 4139-4143, 1990

Fuji, R., Mutho, M., Sumizawa, T., Chen, Z., Yoshimura, A., and Akiyama, S.
Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells.  J. Natl. Cancer Inst. 86, 1781-1784, 1994

Sumizawa, T., Furukawa, T., Haraguchi, M., Yoshimura, A., Takeyasu, A., Ishizawa, M, Yamada, Y., and Akiyama, S.  Thymidine phosphorylase activity associated with platelet-derived endothelial cell growth factor.   J. Biochem. 114, 9-14, 1993

Ichikawa-Haraguchi, M., Sumizawa, T., Yoshimura, A., Furukawa, T., Hiramoto, S., Sugita, M., and Akiyama, S.   Progesterone and its metabolites: the potent inhibitors of the transporting activity of P-glycoprotein in the adrenal gland.     Biochim. Biophys. Acta  1158, 201-213, 1993

Nishiyama, K., Shirahama, T., Yoshimura, A., Sumizawa, T., Furukawa, T.,  Ichikawa-Haraguchi, M., Akiyama, S., and Ohi, Y.  Expression of the multidrug transporter, P-glycoprotein, in renal and transitional cell carcinomas. 
Cancer 71, 3611-3619, 1993

Furukawa, T., Yoshimura, A.,  Sumizawa, T., Haraguchi, M., Akiyama, S., Fukui, K., Ishizawa, M., Yamada, Y.  Angiogenic Factor.  Nature 356, 668, 1992

Ichikawa, M., Yoshimura, A., Sumizawa, T., Shudo, N., Kuwazuru, Y., Furukawa, T.  and Akiyama, S. Interaction of organic chemicals with P-glycoprotein in the adrenal grand,  kidney, and a multidrug-resistant KB cell. J. Biol. Chem. 266, 903-908, 1991

Ichikawa, M., Yoshimura, A., Furukawa, T., Sumizawa, T., Nakazima, Y.  and Akiyama, S.  Glycosylation of P-glycoprotein in a multidrug-resistant KB cell line, and in the human tissues. Biochim. Biophys. Acta 1073, 309-315, 1991

Yoshimura, A., Kuwazuru, Y., Furukawa, T., Yoshida, H., Yamada, K.  and Akiyama, S.  Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors.  Biochim. Biophys. Acta 1034, 107-113, 1990
 
Yoshimura, A., Shudo, N., Ikeda, S., Ichikawa, M.,. Sumizawa, T.,  and Akiyama, S. Novel screening method for agents that overcome classical multidrug resistance in a human cell line.  Cancer Lett. 50, 45-51, 1990

Ichikawa, M., Yoshimura, A., Furukawa, T., Sumizawa, T. and  Akiyama, S.  Modulators of the multidrug-transporter, P-glycoprotein, exist in the human   plasma. Biochem. Biophys. Res. Commun. 166, 74-80, 1990

Kuwazuru, Y., Yoshimura, A., Hanada, S., Utsunomiya, A., Makino, T., Ishibashi, K., Kodama, M., Iwahashi, M., Arima, T. and Akiyama, S.  Expression of the multidrug transporter, P-glycoprotein, in acute leukemia cells and correlation to clinical drug resistance. Cancer 66, 868-873, 1990
 
Kuwazuru, Y., Yoshimura, A., Hanada, S., Ichikawa, M., Saito, T., Uozumi, K., Utsunomiya, A., Arima, T. and Akiyama, S.       Expression of the multidrug transporter, P-glycoprotein, in chronic myelogenous leukaemia cells in blast crisis.  Br. J. Haematol. 74, 24-29, 1990

Kuwazuru, Y., Hanada, S., Furukawa, T., Yoshimura, A., Sumizawa, T., Utsunomiya, A., Ishibashi, K., Saito, T., Uozumi, K., Maruyama, M., Ishizawa, M., Arima, T. and Akiyama, S. Expression of P-glycoprotein in adult T-cell leukemia cells. Blood 76, 2065-2071, 1990

Sudo N., Mizoguchi T., Kiyosue, T., Arita, M., Yoshimura, A., Sakoda, R.  and Akiyama, S.    Two pyridine analogues with more effective ability to reverse multidrug-resistance  and with lower calcium channel blocking activity than their dihydropyridine counterparts. Cancer Res. 50, 3055-3061, 1990
 
Ikeda, S., Sugita, M., Yoshimura, A., Sumizawa, T., Douzono, H.,  Nagata, Y. and Akiyama, S.  Aspergillus species strain M39 produces two naphtho-gamma-pyrones that  reverse drug resistance in human KB cells. Int. J. Cancer  45, 508-513, 1990

Yoshimura, A., Kuwazuru, Y., Sumizawa, T., Ichikawa, M., Ikeda, S., Ueda, T. and Akiyama, S. Cytoplasmic orientation and two-domain structure of the multidrug transporter,  P-glycoprotein, demonstrate with sequence specific antibodies.
J. Biol. Chem. 264, 16202-16291, 1989

Yoshimura, A., Kuwazuru, Y., Sumizawa, T., Ikeda, S., Ichikawa, M., Usagawa, T. and Akiyama, S.  Biosynthesis, processing. and half-life of P-glycoprotein in a human multidrug-resistant KB cell.  Biochim. Biophys. Acta 992, 307-314,1989

Seguchi, T., Yoshimura, A., Ono, M., Shite, S., Kasahara, M., Ebina, Y., Rutter, W. J., and Kuwano, M.  Insulin receptor and altered glucose transport in a monensin-resistant mutant of  Chinese hamster ovary cell. J. Cell Physiol. 139, 229-236, 1989
 
Akiyama, S., Yoshimura, A., Kikuchi, H., Sumizawa, T., Kuwano, M. and Tahara, Y. Synthetic isoprenoid photoaffinity labeling of P-glycoprotein specific to multidrug- resistant cells. Mol. Pharmacol. 36, 730-735, 1989
 
Kamiwatari, M., Nagata, Y., Kikuchi, H., Yoshimura, A., Sumizawa, T., Shudo, N. Sakoda, R., Seto, K. and Akiyama, S. Correlation between reversing of multidrug resistance and inhibiting of [3H]azidopine photolabeling of P-glycoprotein by newly synthesized dihydropyridine analogues in a human cell line.  Cancer Res. 49, 3190-3195, 1989

Yoshimura, A., Seguchi, T., Yoshida, T., Waki, M. and Kuwano, M.   Nobel feature of metabolism of low density lipoprotein receptor in a mouse macrophage cell line, J774.1. J. Biol. Chem. 263, 11935-11942, 1988

Hagino, Y. Mawatari, M., Yoshimura, A., Kohno, K., Kobayashi, M. and Kuwano, M.  Estrogen inhibits the growth of MCF-7 cell variants resistant to transforming growth factor-beta. Jap. J. Cancer. Res. (Gann) 79, 74-81, 1988  

Yoshimura, A., Yoshida, T., Waki, M., Seguchi, T., Ono, M. and Kuwano, M.  Low binding capacity and altered O-linked glycosylation of low density lipoprotein receptor in a monensin-resistant mutant of Chinese hamster ovary cells.
 J. Biol. Chem. 262, 13299-13308, 1987

Yoshimura, A., Kobayashi, T., Hidaka, K., Kuwano, M. and Ohnishi, S.  Altered interaction between Sendai virus and a Chinese hamster cell mutant with defective cholesterol synthesis.  Biochim. Biophys. Acta 904, 157-164, 1987

Yoshida, T., Yoshimura, A., Ono, M., Hori, S. and Kuwano, M.  Altered structure and function of low density lipoprotein receptor in compactin (ML236b) resistant mutants of Chinese hamster cells.   Biochim. Biophys. Acta 921, 575-586, 1987

Tomita, K., Yoshida, T., Yoshimura, A., Ono, M. and Kuwano, M. Chinese hamster ovary cell mutants with defective down-regulation of low density lipoprotein receptors.   J. Biol. Chem. 262, 1398-1404, 1987

Akiyama, S., Shiraishi, N., Yoshimura, A., Nakagawa, M., Yamaguchi, T., Shimada, T. and Kuwano, M.  Enhancement by a synthetic isoprenoid of the toxicity of conjugates of epidermal  growth factor with Pseudomonas exotoxin.
 Biochem. Pharmacol. 36, 861-868, 1987

Yoshimura, A.   Adenovirus-induced leakage of co-endocytosed macromolecules into the cytosol. Cell Struct. Fanct. 10, 391-404, 1985

Yoshimura, A., Yamashina, S. and Ohnishi, S.   Mobilization and aggregation of integral membrane proteins in erythrocytes induced by interaction with influenza virus at acidic pH. Exp. Cell. Res. 160, 126-137, 1985

Ono, M., Mifune, K., Yoshimura, A., Ohnishi, S. and Kuwano, M.  Monensin-resistant mouse Balb/3T3 cell mutant with aberrant penetration of  vesicular stomatitis virus. J. Cell. Biol. 101, 60-65, 1985

Yoshimura, A. and Ohnishi, S. Uncoating of influenza virus in endosome.
J. Virol. 51, 497-504, 1984

Yoshimura, A., Kuroda, K., Kawasaki, K., Yamashina, S., Maeda, T. and Ohnishi, S. Infectious cell entry mechanism of influenza virus.  J. Virol. 43, 284-293, 1982